医生简介:
医疗特长:对妇科常见病具有丰富的临床诊治经验,擅长妇科肿瘤的宫腔镜和腹腔镜诊断和治疗。研究方向:胡争教授是国家科技部重大专项首席科学家(原863计划),国家自然基金金砖五国多国合作项目牵头科学家,青年珠江学者,中山大学“百人计划”一类急需人才,青年杰出人才。研究方向如下:(1)确定宫颈癌中HPV倾向整合于人类基因组特定位点,绘制整合热点图谱;(2)揭示HPV整合入人基因组的具体机制及导致宫颈癌变的病理生理过程;(3)设计针对HPV致癌基因的分子剪辑技术,逆转宫颈癌变主要教育和工作经历:(1)2017.12-今, 中山大学, 附属第一医院, 研究员,副主任医师(2)2016.4-2017.12, 中山大学, 附属第一医院, 研究员,主治医师(3)2013.12-2016.4, 华中科技大学, 同济医学院附属同济医院, 主治医师(4)2012.7-2013.12, 华中科技大学, 同济医学院附属同济医院, 住院医师(5)2009.9–2012.6, 华中科技大学, 同济医学院附属同济医院妇产科学, 博士,导师: 马丁(6)2006.9–2009.6, 华中科技大学, 同济医学院附属同济医院泌尿外科, 硕士,导师: 张旭(7)2001.9–2006.6, 华中科技大学, 同济医学院临床医学, 学士社会兼职:(1)妇科肿瘤领域顶尖杂志Gynecologic Oncology杂志审稿人;(2)华中科技大学附属武汉中心医院马丁院士工作站特聘教授;(3)国家自然科学基金医学部评审专家;(4)中国医师协会整合医学分会委员;(5)国际妇科肿瘤协会会员;(6)国际乳头瘤病毒协会会员。论著:近两年以第一作者或通讯作者发表SCI论文12篇,单篇影响因子最高31.6分(Nature genetics),14分以上论文1篇(其中JCI受邀为当期封面文章),9分以上论文2篇,总影响因子达125分。以下为部分以第一作者或通讯作者发表的SCI论文:(1)Lan Yu #; Xun Tian; Chun Gao; Ping Wu; LimingWang; Bei Feng; XiaominLi; Hui Wang; Ding Ma* ; Zheng Hu*. Genomeediting for the treatment of tumorigenic viral infections and virus-relatedcarcinomas, Frontiers of Medicine (2)Chunliang Shang# ; Wei Wang; Yuandong Liao;Yili Chen; Tianyu Liu;Qiqiao Du; Jiaming Huang; Yanchun Liang;Junxiu Liu; Yunhe Zhao; Luyan Guo; ZhengHu* ; Shuzhong Yao*. LNMICC promotes nodal metastasis of cervical cancer byreprogramming fatty acid metabolism, cancer research, 2018.2.15, 78(4): 877~890(3)Liming Wang# ; Hui Shen; Bei Feng; Da Zhu;Lan Yu; Xun Tian; Ci Ren; (#) Chun Gao; Xiaomin Li; Ding Ma*; Hui Wang*,Zheng Hu*.Reduction in the copy number and expressionlevel of the recurrent human papillomavirus integration gene fragile histidinetriad (FHIT) predicts the transition of cervical lesions, Plos One, 2017.4.17,12(4) (4)Tianyu Liu# ; Jian Chen; Chunliang Shang;Hongwei Shen; Jiaming Huang;Yanchun Liang; Wei Wang; Yunhe Zhao; Duo Liu;Man Shu; Luyan Guo; Zheng Hu*;Shuzhong Yao*. Tripartite motif containing 62 is a novel prognostic marker andsuppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymaltransition in cervical cancer, Journal of Experimental& Clinical CancerResearch, 2016.10.28, 35(1).(5)Zheng Hu# ; Da Zhu# ; Wei Wang# ; Weiyang Li# ; WenlongJia# ; Xi Zeng#; Wencheng Ding; Lan Yu; Xiaoli Wang; Liming Wang; Hui Shen;Changlin Zhang; Hongjie Liu; Xiao Liu; Yi Zhao; Xiaodong Fang; Shuaicheng Li;Wei Chen; Tang Tang; Aisi Fu; Zou Wang; Gang Chen; Qinglei Gao; Shuang Li; LingXi; Changyu Wang; Shujie Liao; Xiangyi Ma; Peng Wu; Kezhen Li; Shixuan Wang;Jianfeng Zhou; Jun Wang; Xun Xu* ; Hui Wang* ; Ding Ma* . Genome-wide profilingof HPV integration in cervical cancer identifies clustered genomic hot spotsand a potential microhomology-mediated integration mechanism, Nature Genetics,2015, 47(2): 158~163.(6)Hu Z# ; Ding W# ; Zhu D; Yu L; Jiang X; Wang X;Zhang C; Wang L; Ji T;Liu D; He D; Xia X; Zhu T; Wei J; Wu P; WangC; Xi L; Gao Q; Chen G; Liu R; LiK; Li S; Wang S; Zhou J; Ma D* ; Wang H* ,TALEN-mediatedtargeting of HPVoncogenes ameliorates HPV-related cervical malignancy, Journal ofClinicalInvestigation, 2015, 125(1): 425~436.(7)Wencheng Ding# ; Zheng Hu# ; Da Zhu# ; Xiaohui Jiang; Lan Yu; Xiaoli Wang; Changlin Zhang; Liming Wang; Teng Ji;Kezhen Li; Dan He; Xi Xia; Dan Liu; Jianfeng Zhou; Ding Ma* ; Hui Wang* . Zincfinger nucleases targeting thehuman papillomavirus E7 oncogene induce E7disruption and a transformed phenotype in HPV16/18-positive cervical cancercells, Clinical Cancer Research, 2014, 20(24): 6495~6503.(8)Zheng Hu# ; Lan Yu# ; Da Zhu; Wencheng Ding; XiaoliWang; Changlin Zhang; Liming Wang; Xiaohui Jiang; Hui Shen; Dan He; Kezhen Li;Ling Xi; Ding Ma* ; Hui Wang* ,Disruption of HPV16-E7 by CRISPR/Cas SystemInduces Apoptosis and Growth Inhibition in HPV16 Positive Human Cervical CancerCells, Biomed Research International, 2014.1.1, 10(1).(9)Da Zhu# ; Xiaohui Jian# ; Yunhui Jiang# ;Wencheng Ding; Changlin Zhang; Hui Shen; Xiaoli Wang; Ding Ma; Zheng Hu* ; Hui Wang* ,Amplificationand overexpression of TP63 and MYC as biomarkers for transition of cervicalintraepithelial neoplasia to cervical cancer,International Journal of Gynecological Cancer, 2014, 24(4): 643~648.(10) Zheng Hu# ; Qing Ai; Hua Xu; Xin Ma; Hongzhao Li; Taoping Shi; Chao Wang;Daojing Gong; Xu Zhang* , Fibulin-5 is down-regulated in urothelial carcinomaof bladder and inhibits growth and invasion of human bladder cancer cell line5637, Urologic Oncology-Seminars and Original Investigations, 2011.8.1, 29(4):430~435.专著:(1)马丁; 汪辉; 祝达; 沈慧; 胡争; 程静, 一种治疗HPV感染的纳米粒制剂及其制备方法,2015.12.25, 中国, ZL201510999391.7 (2)马丁; 汪辉; 胡争; 祝达; 丁文成, 与宫颈癌发生相关的HPV整合的基因位点及其应用,2015.4.30, 中国, CN20150217845.O (3)马丁; 汪辉; 胡争; 丁文成; 于兰, 利用TALEN敲除人乳头瘤病毒E6E7癌基因的方法, 2014.11.24, 中国,CN201410719340.X (4)马丁; 汪辉; 胡争; 丁文成; 于兰, 利用锌指核酸酶敲除人乳头瘤病毒E6E7基因的方法 2014.11.4 中国,ZL201410648225.8其他主要工作成绩(比如获奖情况):目前主持国家科技部传染病重大专项1项,国家自然基金2项(包括国际合作与交流项目),及广州市科技攻关项目等各级基金,总经费逾千万。研究成果多次获得国内外同行的肯定性评价,相关研究结论入选Prime1000,并被Nature、Annual Review ofGenomics and Human Genetics 、Clinical Cancer Research、International Journal of Cancer 等顶级杂志引用。