中山大学附属第一医院

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医生擅长: 擅长治疗鼻腔鼻窦炎性疾病、鼻息肉、鼻肿瘤。

医生简介: 技术特长:呼吸道炎症疾病主要研究方向:1、呼吸道炎症疾病的发病机理及干细胞治疗研究,包括调节性T细胞(Treg)、II型固有淋巴细胞(ILC-2)、调节性树突状细胞(DCs)等免疫细胞亚群在变应性鼻炎、哮喘、鼻窦炎、鼻息肉中的致病作用机制及间充质干细胞(Mesenchymal stem cells, MSCs)对其的防治作用。2、视神经损伤的发病机制及神经保护剂的作用。主持课题13项1、国家自然科学基金优秀青年基金,变应性鼻炎的干细胞干预。No. 81322012,资助额度100万。2014,01-2016,12,正在执行中。主持;2、国家自然科学基金面上项目,以线粒体转移为作用机制的iPSC-MSC对呼吸道变应性炎症上皮细胞的作用探讨。No.81373174资助额度70万。2014,01-2017,12,正在执行中。3、教育部新世纪优秀人才。No. NCET-13-0608, 50万元。主持;4、国家自然科学基金面上项目,81170896,诱导性多能干细胞来源的间充质干细胞对变应性鼻炎的免疫调节作用。2012/01-2015/12, 57万,在研,主持;5、国家自然科学基金青年项目,30801272,LINGO-1与TrkB的分子关系及其拮抗剂与BDNF对青光眼中视网膜节细胞的协同保护作用, 2009/01-2011/12,21万元,已结题,主持;6、中山大学附属第一医院国家杰出青年科学基金培养, 2014, 30万元,主持;7、教育部高等学校博士学科点科研基金新教师基金,00805581160,LINGO-1拮抗剂促进高眼压下视网膜节细胞存活的分子机制研究。2009,01-2011,12,3.6万元,已结题,主持;8、广东省自然科学基金博士启动,NgR1复合体拮抗剂对高眼压损伤后的神经保护作用。(8451008901000852)3万元,2009,01-2010,12,已结题。9、广东省科技计划项目, No. 2011B031800243,诱导性多能干细胞来源的间充质干细胞对变应性鼻炎的免疫调控。资助额度:4万元。2012,01-2014,12,正在执行中。10、广州市科技计划,iPSC-MSC对呼吸道变应性炎症上皮细胞伯调控及以线粒体转移为作用机制的研究。2014-2016, 8万元,在研,主持。11、高校基本科研业务费-中山大学青年教师重点培育基金。以线粒体为靶点的iPSC-MSC对呼吸道变应性炎症上皮细胞的免疫调控,No.13ykzd07, 资助额度:15万元。2013,11-2015,11。12、高校基本科研业务费-中山大学青年教师培育基金,09ykpy25,大鼠不完全性视神经损伤后突触的变化及NgR1拮抗剂对其的干预作用。2009/11-2011/11,15万元,已结题,主持。13、中山大学附属第一医院优秀青年人才支持计划,2011-2015,25万元,在研,主持;人才资助及获奖国家优青,新世纪优秀人才,中山大学优秀青年教师部分发表SCI论文1. Sun YQ, Deng MX, He J, Zeng QX, Wen W, Wong DS, Tse HF, Xu G, Lian Q, Shi J, Fu QL(付清玲,通讯作者). Human Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Allergic Airway Inflammation in Mice. Stem Cells. 2012 Dec;30(12):2692-9. IF=7.7. 2. Fu QL(付清玲), Chow YY, Sun SJ, Zeng QX, Li HB, Shi JB, Sun YQ, Wen W, Tse HF, Lian Q**, Xu G**. Mesenchymal stem cells derived from human induced pluripotent stem cells modulate T-cell phenotypes in allergic rhinitis. Allergy. 2012 Oct;67(10):1215-22. IF=5.88.3. Fu QL(付清玲), Liao XX, Li X, Chen D, Shi J, Wen W, Lee DH,So KF **. Soluble nogo-66 receptor prevents synaptic dysfunction and rescues retinal ganglion cell loss in chronic glaucoma.Invest Ophthalmol Vis Sci. 2011 Oct 28;52(11):8374-80. IF=3.597. 4. Liao XX, Chen D, Shi J, Sun YQ, Sun SJ,So KF,Fu QL (付清玲,通讯作者).The expression patterns of Nogo-a, myelin associated glycoprotein and oligodendrocyte myelin glycoprotein in the retina after ocular hypertension: the expression of myelin proteins in the retina in glaucoma. Neurochem Res. 2011 Nov;36(11):1955-61. Epub 2011 Jun 4.IF=2.240. 5. Fu QL(付清玲), Hu B, Li X, Shao Z, Wu W, Mi S, So KF.LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension. European J Neuroscience. 2010 March,31:1091-1097. IF=3.631.6. Fu QL(付清玲), Li X, Yip HK, Shao Z, Wu W, Mi S, So KF**. Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma.Neuroscience. 2009 . 162 (2): 375–382. IF=3.380. 7. Fu QL(付清玲),Hu B, Wu W, Pepinsky RB, Mi S, So KF**. Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection. Invest Ophthalmol Vis Sci,2008. 49: 975-985. IF=3.597. 8. Zhuang HW, Mo TT, Hou WJ, Xiong GX, Zhu XL, Fu QL(付清玲,共同通讯), Wen WP. Biological characteristics of CD133(+) cells in nasopharyngeal carcinoma. Oncol Rep. 2013 Jul;30(1):57-63. IF+2.39. Han L, Zheng CP, Sun YQ, Wen WP, Fu QL(付清玲,通讯作者). A Bacterial Extract of OM-85 BV Prevents Allergic Rhinitis in Mice. Am J Rhinol Allergy. 2013 Dec 6. [Epub ahead of print]。 IF=1.810. Li X*, Su H*, Fu QL(付清玲,共同第一)*, Guo J, Lee DHS, So K, Wu W, Soluble NgR Fusion Protein Modulates the Proliferation of Neural Progenitor Cells via the Notfch Pathway. Neurochem Res. 2011, December; 36(12): 2363–2372*第一作者11. Fu QL(付清玲), Wu W, Wang H, Li X, Lee VW, So KF**. Up-regulated endogenous erythropoietin/erythropoietin receptor system and exogenous erythropoietin rescue retinal ganglion cells after chronic ocular hypertension. Cellular and molecular neurobiology. Cell Mol Neurobiol. 2008; 28(2): 317-29. IF=1.969. 12. Li X*, Fu QL(付清玲,共同第一)*, Jing XL, Liao XX, Zeng AH, Xiong Y, Liao XX**. Myelin-associated glycoprotein inhibits the neuronal differentiation of neural progenitors. Neuroreport. 2009 ;20(7):708-12. *第一作者. IF=1.656. 13. Fu QL(付清玲), Li X, Shi J, Xu G, Wen W, Lee DH, So KF. Synaptic Degeneration of Retinal Ganglion Cells in a Rat Ocular Hypertension Glaucoma Model. Cell Mol Neurobiol. 2009 ;29(4):575-81. IF=1.969. 14. Chan KC, Fu QL(付清玲),Guo H, So KF, Wu EX. GD-DTPA enhanced MRI of ocular transport in a rat model of chronic glaucoma. Exp Eye Res.2008 Oct; 87(4):334-41. IF=3.259. 15. Chan KC, Fu QL(付清玲), Hui ES, So KF, Wu EX. Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging. Neuroimage. 2008 Apr 15; 40(3): 1166-74. IF=5.895. 16. Fu QL(付清玲), Shen YQ, Gao MX, Dong J, Neveu PJ, Li KS**. Brain interleukin asymmetries and paw preference in mice. Neuroscience. 2003; 116(3): 639-47. IF=3.380. 17. Qingling Fu(付清玲), Xin Li, Chaowu Yan, Kangsheng L, Xiaoxing L. The level of nitric oxide in the cortex correlates well with brain lateralization. Neuroreport. 2004 ;15(9):1465-8. IF=1.656.

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