中山大学肿瘤防治中心

医生擅长： 肿瘤生物学和肿瘤分子病理学
医生简介：
1985年本科毕业于湖南医科大学（现中南大学湘雅医学院），毕业后一直从事病理学的医教研工作，先后在中山医科大学病理教研室和香港中文大学病理学系获得硕士和博士学位。1991年入职于中山大学肿瘤医院病理科担任病理医生，1997年在香港威尔斯亲王医院进修临床病理诊断。临床医疗擅长于肿瘤病理诊断，教学主讲本科生和研究生的《肿瘤病理学》课程，科研上主要研究肿瘤发生发展的分子机制及分子分型，已获得包括5项国家自然基金在内的省部级科研项目16项。发表文章近70篇，其中以第一作者或通讯作者发表SCI文章近30篇。
　　目前担任中国抗癌协会肿瘤专业委员会常委，广东省抗癌协会肿瘤病理专业委员会主任委员，广东省医师病理分会副主任委员、广东省医学会病理专业委员会常务委员以及广东省抗癌协会小儿肿瘤专业委员会常务委员，并担任三本专业杂志编委：《癌症》、《中华肿瘤防治杂志》、《肿瘤防治研究》。

论文发表： 近期发表的主要文章： 　　1， Zhou X, Zhang CZ, Lu SX, Chen GG, Li LZ, Liu LL, Yi C, Fu J, Hu W, Wen JM, Yun JP. miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma. Oncogene 2015;34:965-77. 　　2， Hu W, Lu SX, Li M, Zhang C, Liu LL, Fu J, Jin JT, Luo RZ, Zhang CZ, Yun JP. Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma. Oncotarget 2015;6:6570-83. 　　3， Zhang CZ, Fang EF, Zhang HT, Liu LL, Yun JP. Momordica charantia lectin exhibits antitumor activity towards hepatocellular carcinoma. Invest New Drugs 2015;33:1-11. 　　4， Li LZ, Zhang CZ, Liu LL, Yi C, Lu SX, Zhou X, Zhang ZJ, Peng YH, Yang YZ, Yun JP. miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1. Carcinogenesis 2014;35:469-78. 　　5， Liu LL, Lu SX, Li M, Li LZ, Fu J, Hu W, Yang YZ, Luo RZ, Zhang CZ, Yun JP. FoxD3-regulated microRNA-137 suppresses tumour growth and metastasis in human hepatocellular carcinoma by targeting AKT2. Oncotarget 2014;5:5113-24. 　　6， Liu LL, Zhang MF, Pan YH, Yun JP, Zhang CZ. NORE1A sensitises cancer cells to sorafenib-induced apoptosis and indicates hepatocellular carcinoma prognosis. Tumour Biol 2014;35:1763-74. 　　7， Liu LL, Zhang MF, Pan YH, Yun JP, Zhang CZ. NORE1A sensitises cancer cells to sorafenib-induced apoptosis and indicates hepatocellular carcinoma prognosis. Tumour Biol 2014 　　8， Fu J, Qiu H, Cai M, Pan Y, Cao Y, Liu L, Yun J, Zhang CZ. Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis. Cancer Sci 2013;104:508-15. 　　9， Yi C, Wang Q, Wang L, Huang Y, Li L, Liu L, Zhou X, Xie G, Kang T, Wang H, Zeng M, Ma J, Zeng Y, Yun JP. MiR-663, a microRNA targeting p21(WAF1/CIP1), promotes the proliferation and tumorigenesis of nasopharyngeal carcinoma. Oncogene 2012;31:4421-33. 　　10， Huang Y, Li LZ, Zhang CZ, Yi C, Liu LL, Zhou X, Xie GB, Cai MY, Li Y, Yun JP. Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis. J Transl Med 2012;10:106. 　　11， Cai MY, Luo RZ, Chen JW, Pei XQ, Lu JB, Hou JH, Yun JP. Overexpression of ZEB2 in peritumoral liver tissue correlates with favorable survival after curative resection of hepatocellular carcinoma. PLoS One 2012;7:e32838. 　　12， Wang X, Liang Y, Chen Q, Xu HM, Ge N, Luo RZ, Shao JY, He Z, Zeng YX, Kang T, Yun JP, Xie F. Prognostic significance of SOX2 expression in nasopharyngeal carcinoma. Cancer Invest 2012;30:79-85. 　　13， Li JD, Zhuang Y, Li YF, Feng YL, Hou JH, Chen L, Zhu AN, Wu QL, Yun JP. A clinicopathological aspect of primary small-cell carcinoma of the uterine cervix: a single-centre study of 25 cases. J Clin Pathol 2011;64:1102-7. 　　14， Zhang MF, Lin SX, Yi C, Fu J, Wu QL, Yun JP. Keratocystoma of the parotid gland: case report and immunohistochemical investigation. J Clin Pathol 2010;63:758-60. 　　15， Zhang MF, Zhang ZY, Fu J, Yang YF, Yun JP. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med 2009;7:110. 　　16， Xiao J, Zhang Z, Chen GG, Zhang M, Ding Y, Fu J, Li M, Yun JP. Nucleophosmin/B23 interacts with p21WAF1/CIP1 and contributes to its stability. Cell Cycle 2009;8:889-95. 　　17， Luo R, Zhang M, Liu L, Lu S, Zhang CZ, Yun J. Decrease of fibulin-3 in hepatocellular carcinoma indicates poor prognosis. PLoS One 2013;8:e70511. 　　18， Zhang CZ, Liu L, Cai M, Pan Y, Fu J, Cao Y, Yun J. Low SIRT3 expression correlates with poor differentiation and unfavorable prognosis in primary hepatocellular carcinoma. PLoS One 2012;7:e51703. 　　19， Zhang CZ, Pan Y, Cao Y, Lai PB, Liu L, Chen GG, Yun J. Histone deacetylase inhibitors facilitate dihydroartemisinin-induced apoptosis in liver cancer in vitro and in vivo. PLoS One 2012;7:e39870. 　　20， Liu L, Zhang CZ, Cai M, Fu J, Chen GG, Yun J. Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. PLoS One 2012;7:e41293. 　　21， Zhang CZ, Zhang H, Yun J, Chen GG, Lai PB. Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochem Pharmacol 2012;83:1278-89. 　　22， Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM. Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 2010;51:836-45. 　　23， Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 2009;50:113-21. 　　24， Kuang DM, Zhao Q, Xu J, Yun JP, Wu C, Zheng L. Tumor-educated tolerogenic dendritic cells induce CD3epsilon down-regulation and apoptosis of T cells through oxygen-dependent pathways. J Immunol 2008;181:3089-98. 　　25， Yun JP, Zhang MF, Hou JH, Tian QH, Fu J, Liang XM, Wu QL, Rong TH. Primary small cell carcinoma of the esophagus: clinicopathological and immunohistochemical features of 21 cases. BMC Cancer 2007;7:38. 　　26， Yun JP, Miao J, Chen GG, Tian QH, Zhang CQ, Xiang J, Fu J, Lai PB. Increased expression of nucleophosmin/B23 in hepatocellular carcinoma and correlation with clinicopathological parameters. Br J Cancer 2007;96:477-8. 　　27， Yun JP, Xiang J, Hou JH, Tian QH, Fu J. [Expression of CD56, as a potential diagnostic marker, in small cell carcinoma]. Ai Zheng 2005;24:1140-3. 　　28， Yun JP, Liew CT, Chew EC, Yin XY, Lai PB, Fai YH, Li HK, Jin ML, Ding MX, Li MT, Lin HL, Lau WY. Nuclear matrix protein expressions in hepatocytes of normal and cirrhotic rat livers under normal and regenerating conditions. J Cell Biochem 2004;91:1269-79. 　　29， Yun JP, Chew EC, Liew CT, Chan JY, Jin ML, Ding MX, Fai YH, Li HK, Liang XM, Wu QL. Nucleophosmin/B23 is a proliferate shuttle protein associated with nuclear matrix. J Cell Biochem 2003;90:1140-8.
科研项目： 近年主持的研究课题: 　　(1) 国家自然基金(81372572)：P2-HNF4α促进肝癌细胞增殖的分子机制；2014.1-2017.12。 　　(2) 国家自然基金：81172345／H1617；miR-663在肝癌细胞增殖中的作用及分子机制研究。2012.01～2015.12。 　　(3) 国家自然基金：编号：30973506；MiRNA靶向MIF及其在鼻咽癌浸润转移作用。2009-2011。