医生擅长:
鼻咽癌的诊断与治疗
医生简介:
受教育经历
1995/09月-2000/07:中山医科大学临床医学系,大学本科
2004/09-2006/09:中山大学肿瘤防治中心,临床肿瘤学硕士(硕博连读)
2006/09-2009/07:中山大学肿瘤防治中心,临床肿瘤学博士
工作经历
2000/07-2005/12:中山大学肿瘤防治中心,住院医师
2006/01-2011/12:中山大学肿瘤防治中心,主治医师
2007/11-2008/11:美国匹兹堡大学学习(国家留学基金委联合博士培养)
2012/01至今:中山大学肿瘤防治中心,副主任医师、硕士生导师
荣誉成就:
2012年第三届南粤科技创新优秀学术论文一等奖(论文Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial),第二完成人。
论文发表:
发表论文
1. Chen QY, Wen YF, Guo L, Liu H, Huang PY, Mo HY, Li NW, Xiang YQ, Luo DH,Su n R, Deng MQ, Chen MY, Hua YJ, Guo X, Cao KJ, Hong MH, Qian CN, and Mai HQ. Concurrent Chemoradiotherapy vs Radiotherapy Alone in Stage II Nasopharyngeal Carcinoma: Phase III Randomized Trial. Journal of the National Cancer Institute. 2011;December 7,103(23),1761-70. (IF 14.6)
2. Tang LQ, Chen QY,(共同第一作者),Fan W, Liu H, Zhang L, Guo L, Luo DH, Huang PY, Zhang X, Lin XP, Mo YX, Liu LZ, Mo HY, Li J, Zou RH, Cao Y, Xiang YQ, Qiu F, Sun R, Chen MY, Hua YJ, Lv X, Wang L, Zhao C, Guo X, Cao KJ, Qian CN, Zeng MS, Mai HQ. Prospective study of tailoring whole-body dual-modality [18F]fluorodeoxyglucose positron emission tomography/computed tomography with plasma Epstein-Barr virus DNA for detecting distant metastasis in endemic nasopharyngeal carcinoma at initial staging. J Clin Oncol.2013 Aug 10;31(23):2861-9.(IF 18.038)
3. Luo DH, Chen QY,(共同第一作者),Liu H, Xu LH, Zhang HZ, Zhang L, Tang LQ, Mo HY, Huang PY, Guo X, Mai HQ.The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways. J Transl Med. 2013 Aug 29;11(1):203.(IF 3.46)
4. Li J,Chen QY,(共同第一作者),Mo HY, Zhang YL, Huang ZF, Zeng YX. Immunophenotyping at the Time of Diagnosis Distinguishes Two Groups of Nasopharyngeal Carcinoma Patients: Implications for Adoptive Immuno-therapy. International Journal of Biological Science, 2011; 7(5): 607-617. (IF 3.2)
5. Liu H, Chen QY, (共同第一作者),Guo L, Tang LQ, Mo HY, Zhong ZL, Huang PY, Luo DH, Sun R, Guo X, Cao KJ, Hong MH, Mai HQ. Feasibility and efficacy of chemoradiotherapy for elderly patients with locoregionally advanced nasopharyngeal carcinoma: results from a matched cohort analysis. Radiat Oncol. 2013 Mar 22;8(1):70. (IF 2.11)
6. Tang LQ, Chen QY, (共同第一作者) Guo SS, Chen WH, Li CF, Zhang L, Lai XP, He Y, Xu YX, Hu DP, Wen SH, Peng YT, Liu H, Liu LT, Yan SM, Guo L, Zhao C, Cao KJ, Liu Q, Qian CN, Ma J, Guo X, Zeng MS, Mai HQ. The impact of plasma Epstein-Barr virus DNA and fibrinogen on nasopharyngeal carcinoma prognosis: an observational study.Br J Cancer. 2014 Sep 9;111(6):1102-11. doi: 10.1038/bjc.2014.393. Epub 2014 Jul 22.
7. 陈秋燕,郭翔,麦海强,洪明晃;IGFBP-6与晚期鼻咽癌患者预后的关系以及在鼻咽癌细胞株CNE2增殖中的作用,中山大学学报(医学科学版)2010,31(4):525-529.
8. 陈秋燕,张昌卿,邓满泉,曹素梅,洪明晃,郭翔,麦海强.鼻咽癌患者放疗过程中血清VEGF水平的动态变化.中华肿瘤防治杂志,2009,16(18):1424-1427.
9. 麦海强,徐理华,刘怀,莫浩元,黄培钰,唐林泉,陈秋燕 (通讯作者) ;ET-1通过上调CXCR4表达促进鼻咽癌低转移细胞株6-10B的迁徙,中山大学学报(医学科学版)2011,32(5):616-622.
10. Cai Z, Chen QY, Chen J, Lu Y, Xiao G, Wu Z, Zhou Q. Monocyte chemotactic protein 1 promotes lung cancer–induced bone resorptive lesions in vivo. Neoplasia, 2009,11(3): 228-236.(IF 5.4)
11. Lu Y, Chen QY, Corey E, Xie W, Fan J, Mizokami A. Activation of MCP-1/CCR2 axis promotes prostate cancer growth in bone. Clinical & Experimental Metastasis, 2009,26(2):161-169.(IF 4.1)
12. Zhang L, Chen QY, Liu H, Tang LQ, Mai Hq. Emerging treatment options for nasopharyngeal carcinoma. Drug Des Devel Ther. 2013; 7:37-52. (IF 3.486)
13. Lu Y, Nie D, Witt WT, Chen QY, Shen M, Xie H, Lai L, Dai Y. Expression of the fat-1 gene diminishes prostate cancer growth in vivo through enhancing apoptosis and inhibiting GSK-3 beta phosphorylation. Molecular Cancer Therapeutics, 2008,7(10):3202-3211.(IF 5.2)
14. Wen YF, Qi B, Liu H, Mo HY, Chen QY, Li J, Huang PY, Ye YF, Zhang Y, Deng MQ, Guo X, Hong MH, Cao KJ, Mai HQ. Polymorphisms in the Endothelin-1 and Endothelin A Receptor Genes and Survival in Patients with Locoregionally Advanced Nasopharyngeal Carcinoma. Clinical Cancer Research, 2011; 17(8):2451-2458. (IF 7.3)
15. 陈秋燕,李茵,谢传淼,洪明晃. MRI及CT对鼻咽癌T分期的不同影响.实用肿瘤杂志,2005,20(2):115-117.
16. 李茵,曹卡加,陈秋燕,谢国丰,黄培钰. 颈淋巴结阴性鼻咽癌颈部的放射治疗. 癌症,2005,24(5):627-630.
17. 孙蕊,陈秋燕,李万湖. 加温联合化、放疗对肺癌细胞株凋亡的影响. 中山大学学报(医学科学版) 2005, 26(3):627-630.
18. 陈秋燕,洪明晃,麦海强. 鼻咽癌并腋窝淋巴结转移的诊治分析.肿瘤防治杂志, 2004, 11(12):28-29.
19. He J, Tang XF, Chen QY, Mai HQ, Huang ZF, Li J, Zeng YX. Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapy. Chin J Cancer, 2012, Jan 17. doi: 10.5732/cjc.011.10376. [Epub ahead of print]
20. Chen MY, Wang SL, Zhu YL, Shen GP, Qiu F, Luo DH, Chen QY, Jiang R, Cao KJ, Qian CN, Hong MH. Use of a posterior pedicle nasal septum and floor mucoperiosteum flap to resurface the nasopharynx after endoscopic nasopharyngectomy for recurrent nasopharyngeal carcinoma. Head Neck, 2011, Dec 5. doi: 10.1002/hed.21928. [Epub ahead of print]
21. Li J, Huang ZF, Xiong G, Mo HY, Qiu F, Mai HQ, Chen QY, He J, Chen SP, Zheng LM, Qian CN, Zeng YX. Distribution, characterization, and induction of CD8? regulatory T cells and IL-17-producing CD8? T cells in nasopharyngeal carcinoma. J Transl Med, 2011, Nov 4,9:189.
22. Lv X, Xiang YQ, Cao SM, Qian CN, Li NW, Guo L, Mai HQ, Chen QY, Huang PY, Luo D, Cao KJ, Hong MH, Guo X. Prospective validation of the prognostic value of elevated serum vascular endothelial growth factor in patients with nasopharyngeal carcinoma: more distant metastases and shorter overall survival after treatment. Head Neck, 2011, 33(6):780-5.
23. Cao SM, Yu JK, Chen QY, Li NW, Xiang YQ, Qian CN, Hu X, Zhang CQ, Xie D, Guo X. Detection of nasopharyngeal carcinoma using surface-enhanced laser desorption and ionization mass spectrometry profiles of the serum proteome. Chin J Cancer, 2010, 29(8):721-8.
24. Kong QL, Hu LJ, Cao JY, Huang YJ, Xu LH, Liang Y, Xiong D, Guan S, Guo BH, Mai HQ, Chen QY, Zhang X, Li MZ, Shao JY, Qian CN, Xia YF, Song LB, Zeng YX, Zeng MS. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog, 2010, 6(6):e1000940.
25. Lu X, Guo X, Hong MH, Chen QY, Zeng Q, Xiang YQ. Comparison of the short-term efficacy of two inductive chemotherapy regimens for locally advanced nasopharyngeal caricinoma: docetaxal plus carboplatin versus 5-fluorouracil plus carboplatin. Chin J Cancer, 2010, 29(2):140-4.
26. Guo L, Lin HX, Xu M, Chen QY, Wang CT, Huang PY. Phase I study of TPF neoadjuvant chemotherapy followed by radical radiotherapy in advanced nasopharyngeal carcinoma. Chin J Cancer, 2010, 29(2):136-9.
27. Li J, Zhang XS, Xie D, Deng HX, Gao YF, Chen QY, Huang WL, Masucci MG, Zeng YX. Expression of immune-related molecules in primary EBV-positive Chinese nasopharyngeal carcinoma: associated with latent membrane protein 1 (LMP1) expression. Cancer Biol Ther, 2007, 6(12):1997-2004.
28. Li J, Zeng XH, Mo HY, Rolén U, Gao YF, Zhang XS, Chen QY, Zhang L, Zeng MS, Li MZ, Huang WL, Wang XN, Zeng YX, Masucci MG. Functional inactivation of EBV-specific T-lymphocytes in nasopharyngeal carcinoma: implications for tumor immunotherapy. PLoS One, 2007, 2(11):e1122.
著作编写
郭灵、林焕新主编,麦海强、陈秋燕副主编,鼻咽癌诊断治疗,世界图书出版广东有限公司(2012年)
科研项目:
1. 国家自然科学基金项目(青年项目)(No:81201629),IGFBP-6调控鼻咽癌的分子机制,2013/01- 2015/12,23万元,负责人。
2. 广东省科技计划项目(No:2011B031800161),奈达铂同期放化疗治疗局部区域晚期鼻咽癌的随机对照III期临床试验,2012/01-2014/12,4万元,负责人。
3. 中山大学肿瘤防治中心2015年308项目,同时期放化疗联合自体肿瘤浸润淋巴细胞(TIL)免疫治疗中晚期鼻咽癌患者的II期临床试验,2015/04-2019/04,60万元,负责人。
4.国家自然科学基金项目(面上项目)(No:81072226),ET-1/ETAR通路上调功能性CXCR4基因而促进鼻咽癌转移的机制研究,2011/01-2014/12,35万元,参加(第二)。
5. 国家自然科学基金项目(面上项目)(No:81272576),上调小角质细胞靶向吞噬功能改善放射性脑损伤的机制研究,2013/01-2015/12,64万元,参加(第二)。
6.广东省科技计划项目(No:2011B080701034),辐射及DDP/5-FU作用通路基因SNPs对局部区域晚期鼻咽癌化疗敏感性及预后影响的研究,2012/01-2014/12,6万元,参加(第二)。
7. 广东省科技计划项目(No:2011B031800314),鼻咽癌患者IMRT后放射性耳损伤的危险因素及治疗方法,2012/01-2014/12,4万元,参加(第二)。
8.国家自然科学基金项目(面上项目)(No:81172164), 癌细胞分泌exosome改变CTL细胞功能导致鼻咽癌免疫逃逸的机制研究,2012/01-2014/12,35万元,参加(第三)。
9.国家自然科学基金项目(面上项目)(No:81172041),CCL2/CCR2调控鼻咽癌转移的机制研究,2012/01-2014/12,35万元,参加(第四)。
********
本人觉得陈秋燕医生对病人很耐心,让很多病人和家属都觉得信赖,我非常感谢您治好我了鼻炎,祝你身体健康,工作顺利。
评价医生: 陈秋燕 2011-08-07
********
陈医生,您好!每次我想起你都会从心底里感激您,您是一个好医生,懂得如何关心病人,很理解患者的心情,我在治疗期间因为得到您的帮助才可以度过这个难关,感谢您,祝你一生平安!
评价医生: 陈秋燕 2011-08-06
********
我哥哥是陈医生的患者,目前还在放疗阶段,我是从外地来到广州的,在很短的时间内接触最多的就是陈医生,她真是一个有医德和爱心的好医生,让患者和家属都感到非常亲切,我相信在陈医生和其他优秀的医生的精心治疗下,我哥哥一定能够早日康复,在此,感谢陈医生。
评价医生: 陈秋燕 2011-08-03