张连海

北京大学肿瘤医院胃肠外科主任医师，副教授。兼科研处副处长、分子诊断中心副主任、生物样本库副主任。中国抗癌协会胃癌专业委员会青年委员，中华胃肠杂志通讯编委。2002年底起于北京大学肿瘤医院从事肿瘤外科临床工作及相关基础研究至今，同时负责肿瘤样本库的建设工作。长期从事消化道肿瘤的临床和科研工作，对腹部常见肿瘤主要是胃肠道、肝脏肿瘤的诊治较为熟悉。具有扎实的理论知识和一定的临床技能;研究方向是消化道肿瘤治疗与预后相关的分子标志及小鼠移植瘤模型的药物敏感性研究。发表论文1. Zhang LH, Liu Y,Wang X,Tang Z, Li S, Hu Y, Zong L, Wu X, Bu Z, Wu A, Li Z, Li Z, Huang X, Jia L, Kang Q, Liu Y, Sutton D, Wang L, Luo L, Ji JF.The extent of inflammatory infiltration in primary cancer tissues is associated with lymphomagenesis in immunodeficient mice. Sci Rep. 2015;5:9447.2. Wang X, Liu Y, Shao D, Qian Z, Dong Z, Sun Y, Xing X, Cheng X, Du H, Hu Y, Li Y, Li L, Dong B, Li Z, Wu A, Wu X, Bu Z, Zong X, Zhu G, Ji Q, Wen XZ, Zhang LH**, Ji JF. Recurrent amplification of MYC and TNFRSF11B in 8q24 is associated with poor survival in patients with gastric cancer. Gastric Cancer. 2015 Jan 25. [Epub]3. Zhang L, Wu X, Hu Y, Wang X, He Z, Xie Y, Pan K, Wang N, Dong Z, Zhang L, Ji J. Establishment of a network-based intra-hospital virtual cancer biobank. Biopreserv Biobank. 2015;13(1):43-8.4. Zhang L, Yang J, Cai J, Song X, Deng J, Huang X, Chen D, Yang M, Wery JP, Li S, Wu A, Li Z, Li Z, Liu Y, Chen Y, Li Q, Ji J. A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy. Sci Rep. 2013 Oct 21;3:2992.5. Fan B, Zhang LH*, Jia YN, Zhong XY, Liu YQ, Cheng XJ, Wang XH, Xing XF, Hu Y, Li YA, Du H, Zhao W, Niu ZJ, Lu AP, Li JY, Ji JF. Presence of S100A9-positive inflammatory cells in cancer tissues correlates with an early stage cancer and a better prognosis in patients with gastric cancer. BMC Cancer. 2012 Jul 28;12:316

发表科研论文数篇。曾发表论文 1. Zhang LH, Tian B, Diao LR, Xiong YY, Tian SF, Zhang BH, Li WM, Ren H, Li Y, Ji JF. Dominant expression of 85-kDa form of cortactin in colorectal cancer. J Cancer Res Clin Oncol. 2006;132:113-20.

2. Zhang LH, Qin LX, Ma ZC, Ye SL, Liu YK, Ye QH, Wu X, Huang W, Tang ZY. Allelic imbalance regions on chromosomes 8p, 17p and 19p related to metastasis of hepatocellular carcinoma: comparison between matched primary and metastatic lesions in 22 patients by genome-wide microsatellite analysis. J Cancer Res Clin Oncol. 2003;129:279-86

3. 张连海, 牛兆建, 仲西瑶, 刘毅强, 李子禹, 季加孚. 利用组织芯片研究Fascin在食管癌中的表达. 中国临床医学 2006;6

从事消化道肿瘤的临床和科研工作，对腹部常见肿瘤主要是胃、肠道、肝脏肿瘤的诊治较为熟悉。